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Deerfield Management Company

Last Updated: 11/23/2020

Deerfield Management Company is a Limited Partnership that started in 1994 and is primarily owned and controlled by James E. Flynn. Below is a list of the Top 10 Holdings by value as reported to the SEC through their historical 13F Filings. You can drill down to get a full comprehensive list by expanding the date of interest and clicking on the Full List Link. To see a profile of the company, click here.


Historical 13F Holdings - Top 10 By Value By Date

(click date to expand)

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
INVITAE CORP NOTE 2.000% 9/0 46185LAB9 267693 163385000 PRN DFND 163385000 0 0
MYLAN NV SHS EURO N59465109 196853 13274000 SH DFND 13274000 0 0
IMMUNOMEDICS INC COM 452907108 195986 2304900 SH DFND 2304900 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 172933 115776000 PRN DFND 115776000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 142369 1832767 SH DFND 1832767 0 0
ACUTUS MEDICAL INC COM 005111109 129386 4341799 SH DFND 4341799 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 120099 149600000 PRN DFND 149600000 0 0
DFP HEALTHCARE ACQUISITNS CO UNIT 03/31/2025 23343Q209 114328 10460000 SH DFND 10460000 0 0
CENTENE CORP DEL COM 15135B101 106627 1828000 SH DFND 1828000 0 0
MYOKARDIA INC COM 62857M105 95976 704000 SH DFND 704000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 280641 144832000 PRN DFND 144832000 0 0
MYLAN NV SHS EURO N59465109 195394 12151362 SH DFND 12151362 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 157797 115776000 PRN DFND 115776000 0 0
SCHRODINGER INC COM 80810D103 123269 1346167 SH DFND 1346167 0 0
DFP HEALTHCARE ACQUISITNS CO UNIT 03/31/2025 23343Q209 111661 10460000 SH DFND 10460000 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 108448 1951211 SH DFND 1951211 0 0
NUVASIVE INC NOTE 2.250% 3/1 670704AG0 93062 85000000 SH DFND 85000000 0 0
IMMUNOMEDICS INC COM 452907108 90762 2561000 SH DFND 2561000 0 0
PACIRA BIOSCIENCES COM 695127100 87258 1663000 SH DFND 1663000 0 0
DEXCOM INC NOTE 0.750%12/0 252131AH0 84346 34000000 SH DFND 34000000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
ADAPTHEALTH CORP COM CL A 00653Q102 275198 17199888 SH DFND 17199888 0 0
MYLAN N V SHS EURO N59465109 181177 12151362 SH DFND 12151362 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 174418 5888511 SH DFND 5888511 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 168706 144832000 PRN DFND 144832000 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 133920 115776000 PRN DFND 115776000 0 0
DFP HEALTHCARE ACQUISITNS CO UNIT 03/31/2025 23343Q209 103031 10460000 SH DFND 10460000 0 0
NUVASIVE INC NOTE 2.250% 3/1 670704AG0 88732 85000000 PRN DFND 85000000 0 0
CENTENE CORP DEL COM 15135B101 75285 1267206 SH DFND 1267206 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 66733 8862247 SH DFND 8862247 0 0
HOMOLOGY MEDICINES INC COM 438083107 62740 4037305 SH DFND 4037305 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 191529 144832000 PRN DFND 144832000 0 0
ADAPTHEALTH CORP COM CL A 00653Q102 188855 17199888 SH DFND 17199888 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 171672 4742311 SH DFND 4742311 0 0
MYLAN N V SHS EURO N59465109 163850 8151754 SH DFND 8151754 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 154250 115776000 PRN DFND 115776000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 121856 8862247 SH DFND 8862247 0 0
HOMOLOGY MEDICINES INC COM 438083107 108585 5245638 SH DFND 5245638 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 98482 4289291 SH DFND 4289291 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 84567 3448912 SH DFND 3448912 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 81150 1361345 SH DFND 1361345 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON THERAPEUTICS PUB LTD SHS G46188101 175978 6462634 SH DFND 6462634 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 158106 136032000 PRN DFND 136032000 0 0
MYLAN N V SHS EURO N59465109 151397 7654065 SH DFND 7654065 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 131363 115776000 PRN DFND 115776000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 106012 8923600 SH DFND 8923600 0 0
HOMOLOGY MEDICINES INC COM 438083107 104263 5760368 SH DFND 5760368 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 87813 4568824 SH DFND 4568824 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 55903 2589291 SH DFND 2589291 0 0
BROOKDALE SR LIVING INC COM 112463104 54631 7207239 SH DFND 7207239 0 0
INTERSECT ENT INC COM 46071F103 52884 3109004 SH DFND 3109004 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON THERAPEUTICS PUB LTD SHS G46188101 155491 6462634 SH SOLE 6462634 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 150514 136032000 PRN SOLE 136032000 0 0
MYLAN N V SHS EURO N59465109 142121 7464327 SH SOLE 7464327 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 124841 8923600 SH SOLE 8923600 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 120607 115776000 PRN SOLE 115776000 0 0
HOMOLOGY MEDICINES INC COM 438083107 112730 5760368 SH SOLE 5760368 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 89625 3032987 SH SOLE 3032987 0 0
INTERSECT ENT INC COM 46071F103 70761 3109004 SH SOLE 3109004 0 0
IMMUNOMEDICS INC COM 452907108 69147 4985383 SH SOLE 4985383 0 0
ACCELERON PHARMA INC COM 00434H108 53617 1305174 SH SOLE 1305174 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA PLC SHS G4617B105 170807 6462634 SH DFND 6462634 0 0
HOMOLOGY MEDICINES INC COM 438083107 144946 5227035 SH DFND 5227035 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 143462 8023600 SH DFND 8023600 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 131460 116032000 PRN DFND 116032000 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 100936 100000000 PRN DFND 100000000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 90829 2617543 SH DFND 2617543 0 0
MYLAN N V SHS EURO N59465109 90682 3199789 SH DFND 3199789 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 76417 1608785 SH DFND 1608785 0 0
IMMUNOMEDICS INC COM 452907108 72898 3794783 SH DFND 3794783 0 0
INTERSECT ENT INC COM 46071F103 64492 2005964 SH DFND 2005964 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA PLC SHS G4617B105 133375 6825719 SH DFND 6825719 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 126211 8023600 SH DFND 8023600 0 0
HOMOLOGY MEDICINES INC COM 438083107 116877 5227035 SH DFND 5227035 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 112678 113532000 PRN DFND 113532000 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 92273 100000000 PRN DFND 100000000 0 0
MYLAN N V SHS EURO N59465109 77645 2833741 SH DFND 2833741 0 0
DEXCOM INC NOTE 0.750% 5/1 252131AF4 73718 55000000 PRN DFND 55000000 0 0
VERICEL CORP COM 92346J108 64831 3725900 SH DFND 3725900 0 0
ACCELERON PHARMA INC COM 00434H108 60384 1386541 SH DFND 1386541 0 0
INTERSECT ENT INC COM 46071F103 58569 2078375 SH DFND 2078375 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA PLC SHS G4617B105 129422 6609894 SH DFND 6609894 0 0
HOMOLOGY MEDICINES INC COM 438083107 119490 5227035 SH DFND 5227035 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 99537 99100000 PRN DFND 99100000 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 99400 100000000 PRN DFND 100000000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 94815 1540448 SH DFND 1540448 0 0
DEXCOM INC NOTE 0.750% 5/1 252131AF4 84160 55000000 PRN DFND 55000000 0 0
MYLAN N V SHS EURO N59465109 67421 1842111 SH DFND 1842111 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 65392 2455586 SH DFND 2455586 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 65134 2900000 SH DFND 2900000 0 0
ANAPTYSBIO INC COM 032724106 64598 647466 SH DFND 647466 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
MALLINCKRODT PUB LTD CO SHS G5785G107 130401 6988248 SH DFND 6988248 0 0
HORIZON PHARMA PLC SHS G4617B105 109460 6609894 SH DFND 6609894 0 0
HOMOLOGY MEDICINES INC COM 438083107 106632 5227035 SH DFND 5227035 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 94914 99100000 PRN DFND 99100000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 64108 1300365 SH DFND 1300365 0 0
MYLAN N V SHS EURO N59465109 62960 1742111 SH DFND 1742111 0 0
MYOKARDIA INC COM 62857M105 57544 1159000 SH DFND 1159000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 56664 2573305 SH DFND 2573305 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 55941 2900000 SH DFND 2900000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 55438 75000000 PRN DFND 75000000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
MALLINCKRODT PUB LTD CO SHS G5785G107 124838 8621383 SH DFND 8621383 0 0
MYLAN N V SHS EURO N59465109 104906 2548111 SH DFND 2548111 0 0
HOMOLOGY MEDICINES INC COM 438083107 97746 5227035 SH DFND 5227035 0 0
HORIZON PHARMA PLC SHS G4617B105 93860 6609894 SH DFND 6609894 0 0
AVEXIS INC COM 05366U100 93402 755798 SH DFND 755798 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 91055 99100000 PRN DFND 99100000 0 0
ANAPTYSBIO INC COM 032724106 82675 794338 SH DFND 794338 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 66903 2900000 SH DFND 2900000 0 0
CENTENE CORP DEL COM 15135B101 62840 588000 SH DFND 588000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 57250 75000000 PRN DFND 75000000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
MALLINCKRODT PUB LTD CO SHS G5785G107 130081 5766000 SH DFND 5766000 0 0
MYLAN N V SHS EURO N59465109 105928 2503611 SH DFND 2503611 0 0
HORIZON PHARMA PLC SHS G4617B105 92592 6341894 SH DFND 6341894 0 0
DEXCOM INC COM 252131107 88048 1534211 SH DFND 1534211 0 0
GLAUKOS CORP COM 377322102 85749 3343045 SH DFND 3343045 0 0
AVEXIS INC COM 05366U100 83644 755798 SH DFND 755798 0 0
ANAPTYSBIO INC COM 032724106 81833 812484 SH DFND 812484 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 68886 74100000 PRN DFND 74100000 0 0
LANNET INC COM 516012101 63041 2717287 SH DFND 2717287 0 0
MCKESSON CORP COM 58155Q103 61569 394801 SH DFND 394801 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
AVEXIS INC COM 05366U100 149679 1547386 SH SOLE 1547386 0 0
MCKESSON CORP COM 58155Q103 111982 729000 SH SOLE 729000 0 0
MYLAN N V SHS EURO N59465109 98929 3153611 SH SOLE 3153611 0 0
HORIZON PHARMA PLC SHS G4617B105 87708 6917070 SH SOLE 6917070 0 0
GLAUKOS CORP COM 377322102 83392 2527032 SH SOLE 2527032 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 69513 1860137 SH SOLE 1860137 0 0
DEXCOM INC COM 252131107 69469 1419911 SH SOLE 1419911 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 66895 74100000 PRN SOLE 74100000 0 0
MYOKARDIA INC COM 62857M105 58492 1365039 SH SOLE 1365039 0 0
ISIS PHARMACEUTICALS INC DEL NOTE 1.000%11/1 464337AJ3 48504 45700000 PRN SOLE 45700000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
AVEXIS INC COM 05366U100 189636 2308130 SH SOLE 2308130 0 0
HORIZON PHARMA PLC SHS G4617B105 106811 8998413 SH SOLE 8998413 0 0
NXSTAGE MEDICAL INC COM 67072V103 96102 3833330 SH SOLE 3833330 0 0
GILEAD SCIENCES INC COM 375558103 66428 938515 SH SOLE 938515 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 64002 74100000 PRN SOLE 74100000 0 0
GILEAD SCIENCES INC COM 375558103 53085 750000 SH Call SOLE 750000 0 0
MYLAN N V SHS EURO N59465109 53072 1367119 SH SOLE 1367119 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 52813 1178605 SH SOLE 1178605 0 0
MCKESSON CORP COM 58155Q103 51899 315417 SH SOLE 315417 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 50508 961147 SH SOLE 961147 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
AVEXIS INC COM 05366U100 170056 2236701 SH DFND 2236701 0 0
HORIZON PHARMA PLC SHS G4617B105 161767 10944988 SH DFND 10944988 0 0
NXSTAGE MEDICAL INC COM 67072V103 100456 3744151 SH DFND 3744151 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 83284 90100000 PRN DFND 90100000 0 0
GILEAD SCIENCES INC COM 375558103 81708 1203000 SH DFND 1203000 0 0
MYLAN N V SHS EURO N59465109 79626 2042224 SH DFND 2042224 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 61397 1743229 SH DFND 1743229 0 0
ISIS PHARMACEUTICALS INC DEL NOTE 1.000%11/1 464337AJ3 60243 62500000 PRN DFND 62500000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 56876 1451301 SH DFND 1451301 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 54586 1365000 SH DFND 1365000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA PLC SHS G4617B105 144924 8956988 SH DFND 8956988 0 0
NXSTAGE MEDICAL INC COM 67072V103 111607 4258196 SH DFND 4258196 0 0
AVEXIS INC COM 05366U100 106758 2236701 SH DFND 2236701 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 104446 4654447 SH DFND 4654447 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 103725 928192 SH DFND 928192 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 78342 82600000 PRN DFND 82600000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 69600 1838829 SH DFND 1838829 0 0
MYLAN N V SHS EURO N59465109 67387 1766378 SH DFND 1766378 0 0
ARRAY BIOPHARMA INC NOTE 3.000% 6/0 04269XAA3 62545 45000000 PRN DFND 45000000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 61240 1743229 SH DFND 1743229 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
GW PHARMACEUTICALS PLC ADS 36197T103 133855 1008475 SH DFND 1008475 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 128078 5639727 SH DFND 5639727 0 0
HORIZON PHARMA PLC SHS G4617B105 116656 6434439 SH DFND 6434439 0 0
NXSTAGE MEDICAL INC COM 67072V103 102438 4099175 SH DFND 4099175 0 0
AVEXIS INC COM 05366U100 92174 2236701 SH DFND 2236701 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 80123 82600000 PRN DFND 82600000 0 0
HEALTHWAYS INC NOTE 1.500% 7/0 422245AB6 79222 54382000 PRN DFND 54382000 0 0
ADEPTUS HEALTH INC CL A 006855100 68917 1600861 SH DFND 1600861 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 63332 1743229 SH DFND 1743229 0 0
VANDA PHARMACEUTICALS INC COM 921659108 57168 3435576 SH DFND 3435576 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA PLC SHS G4617B105 226302 13740261 SH DFND 13740261 0 0
NXSTAGE MEDICAL INC COM 67072V103 97679 4505468 SH DFND 4505468 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 90819 991800 SH DFND 991800 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 86700 3673727 SH DFND 3673727 0 0
AVEXIS INC COM 05366U100 85039 2236701 SH DFND 2236701 0 0
ADEPTUS HEALTH INC CL A 006855100 82700 1600861 SH DFND 1600861 0 0
XENOPORT INC COM 98411C100 81468 11572125 SH DFND 11572125 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 75166 82600000 PRN DFND 82600000 0 0
HEALTHWAYS INC NOTE 1.500% 7/0 422245AB6 72000 76925000 PRN DFND 76925000 0 0
VANDA PHARMACEUTICALS INC COM 921659108 67103 5996691 SH DFND 5996691 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA PLC SHS G4617B105 227676 13740261 SH DFND 13740261 0 0
MYLAN N V SHS EURO N59465109 84938 1832535 SH DFND 1832535 0 0
NXSTAGE MEDICAL INC COM 67072V103 82535 5506028 SH DFND 5506028 0 0
HEALTHWAYS INC NOTE 1.500% 7/0 422245AB6 70595 76925000 PRN DFND 76925000 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 70475 82600000 PRN DFND 82600000 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 67937 1675385 SH DFND 1675385 0 0
AETNA INC NEW COM 00817Y108 66451 591465 SH DFND 591465 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 63032 3089785 SH DFND 3089785 0 0
AVEXIS INC COM 05366U100 60928 2236701 SH DFND 2236701 0 0
DAVITA HEALTHCARE PARTNERS I COM 23918K108 60318 822000 SH DFND 822000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA PLC SHS G4617B105 253210 11684801 SH DFND 11684801 0 0
NXSTAGE MEDICAL INC COM 67072V103 100545 4589000 SH DFND 4589000 0 0
DYAX CORP COM 26746E103 84347 2242073 SH DFND 2242073 0 0
ADEPTUS HEALTH INC CL A 006855100 71307 1307908 SH DFND 1307908 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 67602 1675385 SH DFND 1675385 0 0
AETNA INC NEW COM 00817Y108 63949 591465 SH DFND 591465 0 0
DAVITA HEALTHCARE PARTNERS I COM 23918K108 57302 822000 SH DFND 822000 0 0
MYLAN N V SHS EURO N59465109 57098 1056000 SH DFND 1056000 0 0
VANDA PHARMACEUTICALS INC COM 921659108 55829 5996691 SH DFND 5996691 0 0
GILEAD SCIENCES INC COM 375558103 53833 532000 SH Call DFND 532000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA PLC SHS G4617B105 160173 8081407 SH DFND 8081407 0 0
ALLSCRIPTS HEALTHCARE SOLUTN NOTE 1.250% 7/0 01988PAD0 99819 100750000 PRN DFND 100750000 0 0
NXSTAGE MEDICAL INC COM 67072V103 99636 6318050 SH DFND 6318050 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 87771 2282722 SH DFND 2282722 0 0
AETNA INC NEW COM 00817Y108 69589 636039 SH DFND 636039 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 66428 4072809 SH DFND 4072809 0 0
DYAX CORP COM 26746E103 54555 2857773 SH DFND 2857773 0 0
VANDA PHARMACEUTICALS INC COM 921659108 53965 4784157 SH DFND 4784157 0 0
DAVITA HEALTHCARE PARTNERS I COM 23918K108 51788 716000 SH DFND 716000 0 0
MYLAN N V SHS EURO N59465109 51332 1275000 SH DFND 1275000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HORIZON PHARMA PLC SHS G4617B105 425908 12259875 SH DFND 12259875 0 0
ALLSCRIPTS HEALTHCARE SOLUTN NOTE 1.250% 7/0 01988PAD0 103524 100750000 PRN DFND 100750000 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 86303 4072809 SH DFND 4072809 0 0
NXSTAGE MEDICAL INC COM 67072V103 82468 5773050 SH DFND 5773050 0 0
ARRAY BIOPHARMA INC COM 04269X105 68707 9529361 SH DFND 9529361 0 0
DYAX CORP COM 26746E103 65813 2483507 SH DFND 2483507 0 0
VANDA PHARMACEUTICALS INC COM 921659108 60711 4784157 SH DFND 4784157 0 0
MYLAN N V SHS EURO N59465109 59106 871000 SH DFND 871000 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 57340 1376722 SH DFND 1376722 0 0
ARRAY BIOPHARMA INC NOTE 3.000% 6/0 04269XAA3 56942 45000000 PRN DFND 45000000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
CORSICANTO LTD NOTE 3.500% 1/1 220480AB3 1044 1000000 PRN DFND 1000000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
AUXILIUM PHARMACEUTICALS INC COM 05334D107 215504 6267382 SH DFND 6267382 0 0
AUSPEX PHARMACEUTICALS INC COM 05211J102 154769 2949103 SH DFND 2949103 0 0
HORIZON PHARMA PLC SHS G4617B105 150801 11699047 SH DFND 11699047 0 0
ALLERGAN INC COM 018490102 128957 606601 SH DFND 606601 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 90078 5258475 SH DFND 5258475 0 0
AVALANCHE BIOTECHNOLOGIES IN COM 05337G107 87192 1614669 SH DFND 1614669 0 0
NXSTAGE MEDICAL INC COM 67072V103 86270 4811494 SH DFND 4811494 0 0
HORIZON PHARMA INC NOTE 5.000%11/1 44047TAB5 82435 31760461 PRN DFND 31760461 0 0
BLUEBIRD BIO INC COM 09609G100 78047 850932 SH DFND 850932 0 0
AMAG PHARMACEUTICALS INC NOTE 2.500% 2/1 00163UAA4 74866 45020000 PRN DFND 45020000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
AUXILIUM PHARMACEUTICALS INC COM 05334D107 187081 6267382 SH DFND 6267382 0 0
DENDREON CORP NOTE 2.875% 1/1 24823QAC1 151473 222732000 PRN DFND 222732000 0 0
ALLERGAN INC COM 018490102 87562 491399 SH DFND 491399 0 0
NXSTAGE MEDICAL INC COM 67072V103 80633 6141094 SH DFND 6141094 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 75249 5258475 SH DFND 5258475 0 0
AVALANCHE BIOTECHNOLOGIES IN COM 05337G107 70010 2047679 SH DFND 2047679 0 0
HORIZON PHARMA PLC SHS G4617B105 67793 5520566 SH DFND 5520566 0 0
VOLCANO CORPORATION NOTE 1.750%12/0 928645AB6 65326 75500000 PRN DFND 75500000 0 0
AUSPEX PHARMACEUTICALS INC COM 05211J102 64487 2512160 SH DFND 2512160 0 0
AMAG PHARMACEUTICALS INC NOTE 2.500% 2/1 00163UAA4 60342 45020000 PRN DFND 45020000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
DENDREON CORP NOTE 2.875% 1/1 24823QAC1 156485 222732000 PRN DFND 222732000 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 125724 6267382 SH DFND 6267382 0 0
INTERMUNE INC COM 45884X103 102230 2315521 SH DFND 2315521 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 78877 5258475 SH DFND 5258475 0 0
ALLERGAN INC COM 018490102 73475 434199 SH DFND 434199 0 0
VOLCANO CORPORATION NOTE 1.750%12/0 928645AB6 72627 75500000 PRN DFND 75500000 0 0
NXSTAGE MEDICAL INC COM 67072V103 70409 4899721 SH DFND 4899721 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 59742 3884409 SH DFND 3884409 0 0
ARRAY BIOPHARMA INC COM 04269X105 55658 12205673 SH DFND 12205673 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 54813 2428569 SH DFND 2428569 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
HUMANA INC COM 444859102 144282 1280000 SH Call DFND 1280000 0 0
DENDREON CORP NOTE 2.875% 1/1 24823QAC1 133789 183660000 PRN DFND 183660000 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 70464 5258475 SH DFND 5258475 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 69763 2566705 SH DFND 2566705 0 0
LABORATORY CORP AMER HLDGS COM 50540R409 69699 709689 SH DFND 709689 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 68607 2428569 SH DFND 2428569 0 0
QUESTCOR PHARMACEUTICALS INC COM 74835Y101 67518 1039865 SH DFND 1039865 0 0
AUSPEX PHARMACEUTICALS INC COM 05211J102 61181 1988990 SH DFND 1988990 0 0
VOLCANO CORPORATION NOTE 1.750%12/0 928645AB6 59767 60500000 PRN DFND 60500000 0 0
ARRAY BIOPHARMA INC COM 04269X105 57367 12205673 SH DFND 12205673 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
DENDREON CORP NOTE 2.875% 1/1 24823QAC1 116343 183660000 PRN DFND 183660000 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 85270 4113385 SH DFND 4113385 0 0
QUESTCOR PHARMACEUTICALS INC COM 74835Y101 82018 1506297 SH DFND 1506297 0 0
CUBIST PHARMACEUTICALS INC COM 229678107 68870 1000000 SH Call DFND 1000000 0 0
VOLCANO CORPORATION NOTE 1.750%12/0 928645AB6 59747 60500000 PRN DFND 60500000 0 0
ARRAY BIOPHARMA INC COM 04269X105 56289 11235406 SH DFND 11235406 0 0
NXSTAGE MEDICAL INC COM 67072V103 55706 5570639 SH DFND 5570639 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 54988 3981743 SH DFND 3981743 0 0
NUVASIVE INC NOTE 2.750% 7/0 670704AC9 45559 42136000 PRN DFND 42136000 0 0
ANTARES PHARMA INC COM 036642106 45341 10141174 SH DFND 10141174 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
DENDREON CORP NOTE 2.875% 1/1 24823QAC1 110299 177383000 PRN DFND 177383000 0 0
CUBIST PHARMACEUTICALS INC COM 229678107 95325 1500000 SH Call DFND 1500000 0 0
NXSTAGE MEDICAL INC COM 67072V103 66157 5027164 SH DFND 5027164 0 0
ARRAY BIOPHARMA INC COM 04269X105 65841 10585406 SH DFND 10585406 0 0
NUVASIVE INC NOTE 2.750% 7/0 670704AC9 62429 64136000 PRN DFND 64136000 0 0
PFIZER INC COM 717081103 51849 1805000 SH DFND 1805000 0 0
VOLCANO CORPORATION NOTE 1.750%12/0 928645AB6 51660 50000000 PRN DFND 50000000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 48191 928000 SH DFND 928000 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 45288 2488328 SH DFND 2488328 0 0
ABBVIE INC COM 00287Y109 44954 1005000 SH DFND 1005000 0 0

Issuer Title of Class CUSIP Value(1000s) Share SH/PRN Put/Call Investment Discretion Other Manager Sole Shared None
DENDREON CORP NOTE 2.875% 1/1 24823QAC1 84440 114140000 PRN DFND 99999999 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 80671 4850644 SH DFND 4850644 0 0
CUBIST PHARMACEUTICALS INC COM 229678107 72435 1500000 SH Call DFND 1500000 0 0
EXELIXIS INC NOTE 4.250% 8/1 30161QAC8 65448 67000000 PRN DFND 67000000 0 0
NUVASIVE INC NOTE 2.750% 7/0 670704AC9 61050 61136000 PRN DFND 61136000 0 0
NXSTAGE MEDICAL INC COM 67072V103 55834 3909914 SH DFND 3909914 0 0
PFIZER INC COM 717081103 51959 1855000 SH DFND 1855000 0 0
ARRAY BIOPHARMA INC COM 04269X105 49420 10885406 SH DFND 10885406 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 48716 1242759 SH DFND 1242759 0 0
HOLOGIC INC DEBT 2.000% 3/0 436440AC5 47567 47516000 PRN DFND 47516000 0 0

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